Stiffness in stochastic chemically reacting systems: The implicit tau-leaping method

نویسندگان

  • Muruhan Rathinam
  • Linda R. Petzold
  • Yang Cao
  • Daniel T. Gillespie
چکیده

We show how stiffness manifests itself in the simulation of chemical reactions at both the continuous-deterministic level and the discrete-stochastic level. Existing discrete stochastic simulation methods, such as the stochastic simulation algorithm and the ~explicit! tau-leaping method, are both exceedingly slow for such systems. We propose an implicit tau-leaping method that can take much larger time steps for many of these problems. © 2003 American Institute of Physics. @DOI: 10.1063/1.1627296#

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تاریخ انتشار 2003